Community Meeting: Analysis, Management, and Sharing of Antigen Receptor Repertoire Sequence Data

May 29 - June 1, 2015
Simon Fraser University, Vancouver Campus

The Morris J. Wosk Centre for Dialogue & Harbour Centre
Vancouver, British Columbia, Canada

Register to attend | Make your hotel reservation | View the Community Meeting agenda

Many laboratories across a broad spectrum of biomedical institutions are producing massive sequence datasets using next generation sequencing (NGS) to describe antibody and T-cell receptor repertoires.  Such repertoires are essential to understanding the immune response during infection, autoimmune disease, response to vaccination, cancer immunotherapy, etc.  However, the utility of these datasets will only be fully realized when comparisons can be made among studies, and when additional patient data (such as flow cytometric phenotype data, and RNAseq/microarray gene-expression data, and relevant clinical data) are included in the comparisons.

We have formed an Organizing Committee (see below) to initiate a set of meetings and workshops to develop guidelines and recommendations for “best practices” for the generation, use and sharing of NGS data, focussing on the immune response. The purpose of the proposed meetings is to address the challenges involved in managing and analyzing these large datasets.

The Organizing Committee invites you to attend the first Community Meeting May 29-June 1, 2015.  This meeting will comprise 3-4 workshops in which participants will formulate best-practice recommendations for: (i) assuring NGS data quality, (ii) developing and evaluating NGS data analysis tools, (iii) creating a data infrastructure for sharing NGS data sets, and (iv) solving the ethical, legal, and logistical challenges inherent in dealing with these databases. We plan to bring together members of the burgeoning industry that uses this technology with the academic and not-for-profit research institutions that use and could be sharing NGS data, and with the agencies that support these enterprises.  We expect to develop action plans and recommendations that will be used to make repertoire NGS data production, analysis and sharing across academia and industry as seamless as possible, while recognizing the rights of and responsibilities to the donor communities and taxpayers. This will also necessitate partnering with funding and policy-making agencies in the US, Canada, Europe (and elsewhere). The Community Meeting may be followed by more in-depth workshops specific to different areas, if that is decided at the May meeting.

If you have questions, please contact the Organizational Facilitators. 

Organizational Facilitators:

Workshop Leaders:

  • Workshop 1: George Georgiou & Danny Douek
  • Workshop 2: Rob Holt & Thomas Kepler (Saturday), Lindsay Cowell & Steven Kleinstein (Sunday)
  • Workshop 3: Yann Joly & Bob Cook-Deegan

Organizing Committee:

  • Sohail Ahmed
  • Sanchita Bhattacharya
  • Felix Breden
  • Robert Cook-Deegan
  • Brian Corrie
  • Lindsay Cowell
  • Danny Douek
  • George Georgiou
  • Yvo Graus
  • Rob Holt
  • Yann Joly
  • Tom Kellam
  • Thomas Kepler
  • Marie-Paule Lefranc
  • Nishanth Marthandan
  • Tony Moody
  • Rik Rademaker
  • Jamie Scott



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